Fuel Cells in Brain Can Also Release Damaging Toxins

Oct. 25, 2021 — Star-shaped cells in our brains referred to as astrocytes play a vital position in serving to us assume, transfer, and breathe. They nourish our neurons, the cells that transmit messages all through our mind and nervous system to regulate our bodily capabilities.

A brand new research in mice means that astrocytes additionally might play a damaging position in our brains. When these cells encounter injured neurons, they launch poisonous fatty acids that might contribute to the tissue harm that happens with dementia and different neurodegenerative ailments.

After researchers made this discovery utilizing mice, they genetically engineered the animals to dam manufacturing of those fatty acids. Their goal was to see if stopping manufacturing of those toxins prevented nerve cell destruction.

In the modified mice, 75% of the nerve cells survived, in contrast with 10% of such cells in animals with usually functioning astrocytes, in accordance with the findings, which have been revealed in Nature.

These poisonous fatty acids don’t have an effect on wholesome cells, the research workforce famous. The results could also be confined solely to nerve cells which are broken, injured, or mutated.

These findings are preliminary, and the strategies the investigators utilized in mice aren’t prepared for use in human research. The researchers recommend that halting manufacturing of the fatty acids would possibly sooner or later be used to deal with circumstances comparable to dementia, a number of sclerosis, Parkinson’s illness, and Huntington’s illness. The method could be safer than attacking astrocytes instantly, as they nonetheless are wanted to nourish wholesome neurons.