Oct. 12, 2022 – Another stoner stereotype bites the mud: Despite its appetite-boosting results – higher often called the “munchies” – hashish may very well assist hold your weight in test.

 Cannabis customers could also be much less more likely to turn out to be overweight than individuals who abstain, in accordance with a latest examine within the journal Health Economics. The examine tracked well being information from the state of Washington earlier than and after 2014, the 12 months hashish turned broadly accessible there for leisure use. 

According to the examine: “Marijuana legalization, which allowed for recreational marijuana dispensaries to open, resulted [in] decreases in obesity rates for Washington State.” 

During the 4 years after legalization, the state’s weight problems charge was 5.4% decrease, on common, than it will have been had hashish not been legalized. 

How Did They Figure That Out? 

The researchers arrange one thing known as an artificial counterfactual. 

“It’s the best approximation of what Washington would have looked like had it not legalized marijuana,” says lead writer Raymond March, PhD, an assistant professor of utilized economics at North Dakota State University. March and his colleagues got here up with a inhabitants that is like Washington state’s by combining information from states that didn’t legalize throughout those self same 4  years, together with Arizona, Minnesota, Kansas, and New Hampshire.

Hence the “synthetic counterfactual” – what Washington may need seemed like had it not legalized. The authors conclude that the state would have had 5.4% extra overweight folks over the “post-treatment period” – the 4 years after legalization – with the medical bills and human distress that go together with such obesity-related situations as diabetes, coronary heart illness, stroke, and elevated threat of early dying. 

The researchers additionally in contrast Washington state’s weight problems numbers with the nationwide development. Both development upward, however after 2014, Washington’s charge of enhance declined considerably. 

Why Might This Be Happening?

Thomas Clark, PhD, a physiologist with the Department of Biological Sciences at Indiana University in South Bend, addressed one potential purpose in a 2018 examine within the journal Cannabis and Cannabinoid Research. According to the examine, “Cannabis use appears to reverse the impact of the modern American diet on health by reducing the effects of an elevated ratio of omega-6/omega-3 fatty acids on endocannabinoid (eCB) tone.” 

Clark explains: “The 1970s saw increasing obesity in the United States, and it’s still rising today. It began with the government subsidies of corn- and soybean oil, which alter the body’s physiological regulation of metabolism. When you alter the balance of omega-6 fatty acids and omega-3 fatty acids – which you do by increasing vegetable oils such as soybean oil in the diet – the body’s endocannabinoid system becomes overactive, resulting in weight gain.” 

The endocannabinoid system – which promotes homeostasis, or steadiness, within the physique – is regulated by signaling molecules which are mimicked by chemical substances in hashish. Yes, hashish stimulates urge for food, therefore its therapeutic use by folks with illnesses like AIDS, or who’re getting appetite-killing remedies like chemotherapy. But in accordance with Clark, it additionally down-regulates the endocannabinoid system, bringing it into steadiness, stopping weight achieve, and, theoretically at the very least, serving to the folks of Washington gradual the tide of weight achieve of their state.

“My research indicates that we should look at these metabolic diseases and their correlation with cannabis use,” he says. “There may be a significant health benefit to cannabis use.”

If these advantages could be confirmed, hashish is perhaps one reply to the swelling waistlines and well being dangers of the American public.

The post Could Pot Prevent a Pot Belly? Researchers Get the Skinny on Cannabis appeared first on Healthy and Slim Life.

THURSDAY, Aug. 4, 2022 (HealthDay News) — Researchers are reporting early however encouraging findings on a possible new approach to forestall malaria — an outdated foe that also ranks as a serious killer worldwide.

In a small trial of wholesome volunteers, U.S. authorities researchers discovered {that a} lab-engineered antibody protected most individuals from an infection with the malaria parasite — together with all of those that acquired the next dose of the antibody.

The investigators additionally confirmed it was attainable to offer the antibody with a regular injection, slightly than the IV infusions usually used to ship monoclonal antibodies. That might be essential, the researchers mentioned, to be used within the “actual world.”

Experts cautioned that a lot work stays. But additionally they described the findings as an “thrilling” growth in opposition to a serious killer of kids in growing nations.

Malaria is brought on by a parasite that’s transmitted by sure varieties of mosquitoes. Despite varied prevention efforts — from insecticide-treated mattress nets to disease-preventing drugs — malaria continues to precise an enormous toll.

In 2020, greater than 240 million individuals contracted malaria and over 600,000 died — principally kids youthful than 5 in sub-Saharan Africa.

“Imagine being a mother or father dwelling in a spot with excessive malaria transmission,” mentioned Dr. Robert Seder, of the U.S. National Institute of Allergy and Infectious Diseases. “Your youngster might die of a mosquito chew.”

Last yr noticed a serious step in battling the illness: The World Health Organization accredited the first-ever malaria vaccine, to be used in younger kids. The vaccine, referred to as Mosquirix, is given in three doses between the ages of 5 and 17 months, with a fourth dose about 18 months later.

While the vaccine was welcomed as a breakthrough, it isn’t a house run. On common, it reduces a baby’s danger of malaria by about 36% over 4 years.

“We need to enhance upon that,” mentioned Seder, the senior researcher on the brand new research.

Creating a extremely efficient vaccine in opposition to malaria is troublesome, Seder defined, because of the complexity of the parasitic an infection.

The malaria parasite goes by means of completely different life levels within the human physique. When an contaminated mosquito bites somebody, it “spits” a small variety of parasites into the blood, in a type referred to as a sporozoite. Those sporozoites then journey to the liver, the place they multiply and mature.

Eventually, the parasites make their approach into blood cells, which is after they trigger sickness — usually a fever and different flu-like signs. Without immediate remedy, there will be extreme problems like organ failure and mind swelling.

Seder and his colleagues have been growing a distinct method to prevention: a monoclonal antibody that acknowledges a protein on the sporozoite’s floor, with the goal of conserving it from invading the liver. The antibody is a lab-modified model of a pure one which was remoted from a affected person who’d been vaccinated in opposition to malaria.

In idea, a monoclonal antibody might work higher than a vaccine, Seder mentioned: Vaccines depend on coaching the immune system to supply antibodies in opposition to a international invader, and that response will differ from individual to individual.

Monoclonal antibodies are extra predictable.

“They’re delivered at a protecting dose, like filling up a fuel tank,” mentioned Dr. Johanna Daily, an infectious illness specialist at Albert Einstein College of Medicine, in New York City.

Daily, who research malaria, wrote an editorial revealed Aug. 4 with the brand new findings within the New England Journal of Medicine.

“I’m enthusiastic about this,” Daily mentioned of the antibody method.

Monoclonal antibodies are “very particular” to the invader they’re focusing on, she mentioned, and if this one will be delivered by a regular jab, that may make it possible to be used within the nations the place it is most wanted.

The present research concerned 23 wholesome U.S. adults, 17 of whom got the monoclonal antibody, both by IV or injection. The remaining six served as a comparability group. All have been voluntarily uncovered, beneath managed situations, to mosquitoes carrying the malaria parasite.

Of the 17 who’d acquired the antibody, 15 have been utterly protected, displaying no detectable parasite of their blood three weeks after the managed an infection. That included all volunteers given the next dose of the antibody.

In distinction, all six individuals within the comparability group had parasites of their blood (and have been handled with normal malaria medication).

The antibody Seder’s staff used is a stronger type of one they examined in an earlier trial, revealed a yr in the past. The researchers estimate that this new model might, after one injection, shield a younger youngster in opposition to malaria for six to 12 months.

“We’ve proven you can give it by means of the usual route, as a substitute of IV, and you do not have to offer very a lot — which will get on the value difficulty,” Seder famous.

The draw back of monoclonal antibodies is that they’re ultimately depleted, and injections would should be repeated to get kids by means of the high-risk years.

An upside, Seder mentioned, is that the entire engineered antibodies are extremely focused to the parasite — versus the numerous response a vaccine produces, the place some antibodies are very efficient and others not a lot.

“It’s like having a staff the place everyone seems to be Michael Jordan,” Seder mentioned.

An actual-world research of the method is already underway in Mali, and one other is ready to start in Kenya, Seder famous.

If the tactic proves efficient, Daily mentioned, one query might be methods to match it in with present prevention efforts, together with the vaccine. One risk, Seder mentioned, might be to vaccinate infants, then give the antibody as a booster — maybe yearly, over a number of years.

A bigger query, for each the vaccine and antibody, is whether or not the parasite will evolve to evade them. That’s one thing that solely time will inform, Daily mentioned.

More info

The U.S. National Institute of Allergy and Infectious Diseases has extra on malaria.

SOURCES: Robert Seder, MD, Vaccine Research Center, U.S. National Institute of Allergy and Infectious Diseases, Bethesda, Md.; Johanna Daily, MD, MS, professor, drugs, microbiology and immunology, Albert Einstein College of Medicine, Bronx, N.Y.; New England Journal of Medicine, Aug. 4, 2022

The post Monoclonal Antibody Might Help Prevent Malaria appeared first on Healthy and Slim Life.

SOURCES:

Irwin Goldstein, MD, director, sexual drugs, Alvarado Hospital, San Diego. Research funding: Pfizer. Research research: Vivus and Medtronic.

J. Stephen Jones, MD, chairman, division of regional urology, Cleveland Clinic. Consultant: Pfizer.

Andrew McCullough, MD, affiliate professor of scientific urology and director, male sexual well being program, New York University Langone Medical Center. Lecturer: Auxillium. Research grant: Pfizer. Data security monitoring board: Pfizer. Consultant: Slate Pharmaceuticals. Clinical trials: Warner Chilcott, Vivus, Lilly, Bayer-GSK, ICOS, Timm, Schering Plough, Aeterna.

Ira Sharlip, MD, scientific professor of urology, University of California San Francisco School of Medicine. Advisory board member and/or audio system bureau: Pfizer, Lilly, Johnson & Johnson, Shionogi, Boehringer Ingelheim, Plethora Solutions.

American Heart Association: “Mediterranean Diet.”

Medline Plus: “Erectile Dysfunction.”

National Institute for Occupational Safety and Health: “No-nose Saddles for Preventing Genital Numbness and Sexual Dysfunction from Occupational Bicycling.”

National Kidney and Urologic Diseases Information Clearinghouse: “Erectile Dysfunction.”

The post 11 Tips to Help Prevent Erectile Dysfunction appeared first on Healthy and Slim Life.

Jan. 27, 2022 — It’s no secret {that a} specific public well being epidemic has solely gotten worse through the COVID-19 pandemic: drug overdose deaths. From May 2020 to April 2021, greater than 100,000 folks within the U.S. died from a drug overdose, in response to the CDC. About 64% of these deaths have been from opioids, largely fentanyl.

To cut back these deaths, researchers from the University of Washington have developed a brand new wearable gadget that may inform when an individual is overdosing from opioids.

It’s potential to reverse an opioid overdose with the drug naloxone, however it must be given as quickly as somebody exhibits indicators of an overdose or stops respiration. If an individual is having an overdose alone, or if nobody close by has a naloxone dose or the coaching to manage it, that particular person’s chance of dying is way larger. This prompted the researchers to develop an auto-injector system that folks with opioid use dysfunction can put on towards their stomach. The new gadget works so much like an insulin pump.

It has sensors to detect respiration patterns and is programmed to acknowledge the indicators of slowed or stopped respiration and motion. If the sensors detect life-threatening respiration signs that imply an overdose, it triggers a shot of naloxone. The researchers examined the gadget in volunteers in two environments and revealed their findings within the journal Scientific Reports in November.

One of the check websites was a supervised injection clinic in Vancouver, Canada, the place folks with dependancy can use IV medicine with a educated medical skilled current. Twenty-five volunteers wore the gadget to make sure it precisely measured their respiration patterns whereas utilizing opioids, however the units weren’t programmed to ship the naloxone.

The different website was a hospital the place 20 volunteers who didn’t take opioids wore the units and held their breath for 15 seconds to imitate the symptom of stopping respiration. During this check, the units did inject a naloxone dose after they sensed that the particular person had not moved for not less than 15 seconds.

Naloxone attaches to opioid receptors and reverses and blocks the results of different opioids if they’ve been consumed. After the pictures, the members had their blood taken to ensure the small dose of drug entered their bloodstream.

The new research exhibits that the gadget acts because it ought to and delivers the fitting dose into an individual’s circulatory system. That mentioned, extra research is required earlier than the researchers can apply for approval from the FDA. Also, along with extra exams on the units’ security and effectiveness, the researchers must understand how comfy the units are to put on and whether or not they’re hidden sufficient from view that folks with an opioid dependancy could be prepared to put on them.

The post New Wearable Device Could Help Prevent Overdose Deaths appeared first on Healthy and Slim Life.

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Dr. Carl Bamlet
Doctor of Chiropractic, Certified Nutrition Specialist

Dr Alan Christianson
Naturopathic Medical Doctor

Dr Victoria Flight
General Medicine Practitioner, Nutrition Specialist

Samantha McSorley
Herbalist, Naturopath

Diane V Capaldi
Founder of Paleo Boss Lady

Dr Eric Wood
Naturopathic Physician

Dr Rodney Ford
Pediatrician, Assoc. Professor

Elora Harre
Founder of The Shrinking Violet

Mark Webster
Naturopathic Pharmacist

Kippy Miller
Founder of Kippy’s! Non-Dairy Ice Cream Shop

Dr. Jennifer Lamoureux
Pharmacist, Founder of Egyptian Smoothie Detox

Rachel McClelland
Founder of South Beach PrimalFounder of Dinner For Mary

Durgadas Lingham
Ayurvedic Practitioner

Lisa Willert
Founder of Everybody’s Butchery

Michelle Joy Kramer
Holistic Health Practitioner

Dr. Susan Peirce Thompson, Ph.D
Founder of Bright Line Eating

Dr Cade Copeland
Doctor of Chiropractic

Drew Canole
Author, Fitness Specialist

Summer Bock
Holistic Health Coach

Ari Whitten
Author, Fat Loss & Nutrition Expert

Paul Greive
Farmer at Primal Pastures

Dr. Izabella Wentz
Author, Thyroid Pharmacist

Ben Ceccarelli
Founder of Dinner For Mary

Dr. John O’Malley
Doctor of Chiropractic

Vandana Sheth, RDN
Nutritionist, Certified Diabetes Educator

Dr. Catherine Heinlein
Nutritionist, Certified Diabetes Educator

Lauren Kanzler, CCN
Nutritionist, Diabetes Specialist

Kirsty Higgins
Fitness Specialist

Walid Abdul-Wahad
Founder of Desert Farms, Inc.

Lisa Lewtan
Holistic Health Practitioner

Dr. Pedram Shojai, OMD
Author & Filmmaker

Dr Judith Thompson
Naturopathic Consultant

Laura Grammatico
Certified Holistic Health Educator

Dr Charles Livingston
Author, Doctor of Chiropractic

Dr Robin Bernhoft
Occupational Medicine Specialist

Julianne Taylor
Nutritionist

Leanne Ely
Author, Nutritionist

Gary Watson
Author, Founder of Wake the Fork Up

Sean Ghazzara
Fitness Specialist

Perla Bucknell
Yoga Instructor

Gina Broom
Wellness & Lifestyle Blogger

Leigh O’Brien
Registered Dietitian

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Episode 9: Is Soy Causing Sickness? Learn in regards to the REAL results of soy on folks, the way it can throw off their pure hormonal stability – particularly in kids.

Learn how you can get off the soy practice and unlearn the narrative we’ve been fed for years.

Episode 10: Beating Inflammation & Joint Pain – Find out how you can cope with osteoarthritis in addition to rheumatoid arthritis. Most folks don’t notice that each situations have a variety of similarities, which makes it simpler to deal with each!

You’ll additionally learn to get rid of the vital components that contribute to irritation, so you’ll be able to reside a pain-free life and restore your mobility.

You’ll additionally learn to get rid of the vital components that contribute to irritation, so you’ll be able to reside a pain-free life and restore your mobility.

Episode 11: Exploring the Links Between Food & Depression – we’ll reveal the large affect weight problems has on psychological well being. Find out the position meals performs in combating signs of despair and bettering your emotional state.

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MONDAY, Dec. 6, 2021 (HealthDay News) — Viagra, a drug lengthy used to deal with erectile dysfunction, could double as a possible weapon towards Alzheimer’s illness, a brand new examine suggests.

Looking at information on greater than 7 million Americans, researchers discovered that these taking the drug had been 69% much less more likely to develop Alzheimer’s, when in comparison with non-users.

Then, in lab experiments, the investigators confirmed that the remedy appeared to focus on a part of the underlying illness course of in Alzheimer’s.

Still, the findings mustn’t ship anybody operating to the physician for a Viagra prescription, the researchers cautioned.

But they do argue for scientific trials to check the drug towards Alzheimer’s, mentioned senior researcher Feixiong Cheng, of Cleveland Clinic’s Genomic Medicine Institute.

Viagra, bought generically as sildenafil, was accredited over 20 years in the past for treating erectile dysfunction. Sildenafil was later accredited underneath a special model identify (Revatio) for pulmonary hypertension, a type of hypertension affecting the lungs.

The drug works by inhibiting a protein referred to as phosphodiesterase-5, which in flip permits blood vessels to loosen up and widen, enhancing blood circulate.

But phosphodiesterases additionally exist within the mind, Cheng mentioned. And current lab analysis has prompt sildenafil could inhibit the irregular protein buildup that could be a hallmark of Alzheimer’s illness. In lab mice engineered to have an Alzheimer’s-like situation, sildenafil has proven motion towards these proteins, and boosted reminiscence and brain-cell formation.

The new findings, printed on-line Dec. 6 within the journal Nature Aging, bolster the case for learning the drug as an Alzheimer’s remedy, Cheng mentioned.

If that occurs, sildenafil would be a part of a rising record of accredited medication that researchers hope to “repurpose” as therapies for Alzheimer’s.

Medications for circumstances starting from diabetes to hypertension to most cancers are already being investigated for that very function, mentioned Dr. Howard Fillit, founding govt director of the nonprofit Alzheimer’s Drug Discovery Foundation.

The basis was amongst a number of funders of the present examine, the first one being the U.S. National Institutes of Health.

Fillit agreed that the findings ought to assist transfer sildenafil into Alzheimer’s trials. Ultimately, he mentioned, everybody believes it is going to take a number of approaches, and mixtures of medicines, to battle a illness as advanced as Alzheimer’s.

“We’ll want a number of therapies to focus on the totally different ways in which issues go incorrect within the mind in Alzheimer’s,” Fillit defined.

Repurposing accredited medicines has apparent benefits over ranging from scratch to develop new therapies. Approved medication have a identified security observe file, and they are often dropped at trials comparatively shortly, with much less expense.

Of course, Fillit mentioned, there needs to be a rationale for selecting which medication to repurpose.

For the most recent examine, Cheng’s workforce began with the premise that medication affecting two proteins — amyloid and tau — would have the best potential towards Alzheimer’s. The illness is marked by an irregular clumping of these proteins within the mind, generally often called plaques and tangles.

Research has proven, Cheng mentioned, that the interplay between amyloid and tau is extra necessary than both alone within the Alzheimer’s course of.

His workforce screened over 1,600 accredited medicines, utilizing genetic and different organic information, and finally landed on sildenafil as one of the best candidate as a attainable Alzheimer’s remedy.

Next they used medical health insurance claims from over 7 million Americans to see whether or not sildenafil customers had been at decrease danger of Alzheimer’s. And on common, they had been 69% much less more likely to be identified with the mind illness over six years, versus non-users.

The lowered danger was seen amongst individuals with coronary heart illness, hypertension or diabetes — all danger elements for dementia — in addition to individuals with out these circumstances, Cheng mentioned.

Sildenafil customers even had a decrease Alzheimer’s danger when put next towards individuals on the blood stress drug losartan or the diabetes remedy metformin — each at present underneath examine for battling dementia.

Finally, in experiments with cells taken from Alzheimer’s sufferers, the researchers discovered that sildenafil appeared to inhibit tau and assist mind cell progress.

“This helps the conduct of a scientific trial, after which we’ll have a solution,” Fillit mentioned. “We will not know till we have now trials.”

And though most present sildenafil customers are males, these trials ought to embody each sexes, Cheng’s workforce identified.

For now, Fillit mentioned individuals may help defend their mind well being via way of life selections, together with common train, consuming a nutritious diet, not smoking and getting circumstances comparable to hypertension and diabetes underneath management.

“That’s good not solely to your coronary heart, however your mind, as properly,” he mentioned.

More data

The Alzheimer’s Association has extra on Alzheimer’s danger discount.

SOURCES: Feixiong Cheng, PhD, assistant employees, Genomic Medicine Institute, Cleveland Clinic, Ohio; Howard Fillit, MD, founding govt director, chief science officer, Alzheimer’s Drug Discovery Foundation, New York City; Nature Aging, Dec. 6, 2021, on-line

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